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. 2023 Jun 22;18(7):1516–1533. doi: 10.1016/j.stemcr.2023.05.018

Figure 3.

Figure 3

PSEN1 L435F reduces neuronal differentiation

(A and B) (A) TUJ1 IHC and (B) quantification of male control and PSEN1 L435F hCSs at 30 DIV.

(C and D) (C) MAP2 IHC and (D) quantification in male hCSs at 30 DIV.

(E and F) (E) TUJ1 IHC and (F) quantification in male hCSs at 60 DIV.

(G and H) (G) MAP2 IHC and (H) quantification in male hCSs at 180 DIV. N = 10–12 hCSs from 4 individual replicates, including outliers. p values from unpaired t tests and Cohen’s d value for effect size are shown. Scale bars, 500 and 75 μm (inset). Data are presented as mean ± SEM.