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. 2023 Jun 22;18(7):1516–1533. doi: 10.1016/j.stemcr.2023.05.018

Figure 6.

Figure 6

PSEN1 L435F affects AD-related pathology

(A) Representative IHC of Aβ, MAP2, and GFAP at 180 DIV in male control and PSEN1 L435F hCSs. Scale bars, 250 and 25 μm (inset).

(B) Quantification of Aβ IHC at 180 DIV. N = 9–12 hCSs from 4 independent replicates.

(C) ELISA results of Aβ40, Aβ 42, and Aβ 43 at 175 DIV in hCS medium.

(D) Ratios of Aβ42/40 and Aβ43/40 from ELISA. N = 9 hCSs from 3 independent replicates of hCSs. p values from individual t tests and effect sizes are displayed. Data are presented as mean ± SEM.