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PSEN1 L435F reduces extracellular activity
(A) Experimental schematic for MEA recordings and analysis from male control and PSEN1 L435F hCSs at 180–190 DIV.
(B) MEA results from hCSs displayed as spikes/10-min recording. Baseline is average of two 10-min recordings, all others are one 10-min recording. N = 19 hCSs from 3 individual replicates. p values from individual t tests and effect sizes are displayed. Data are presented as mean ± SEM.
