Figure 2.

Conditional deletion of Srr leads to defects in adult SVZ neurogenesis and proliferation

(A) Expression of SR in SR^flox/flox and nestin-cre+ mice brain.

(B) BrdU incorporation (red) and GFAP expression (green) in the SVZ of SR^flox/flox and nestin-cre+ mice. Scale bar, 100 μm.

(C) Quantitative estimation of BrdU+ cells counted in different high-powered fields per section. n = 4–5 mice.

(D) Expression of Ki67 in SVZ.

(E–J) Densitometric analysis of blot in (D). Expression of NSC and proliferation markers (F) MCM2, (G) Prominin, (H) SOX2, (I) NCAM, and (J) mCD24 in SR^flox/flox and nestin-cre+ mice. Scale bar, 20 μm.

(K) Expression of OMP in SVZ.

(L) Densitometry of OMP blot.

(M) Expression of DLX2 and OLIG 2 in SVZ.