Figure 2.
The mechanisms by which m6A modification regulates macrophages
METTL3 (a writer) promotes production of TNF-α by enhancing degradation of Irakm (an inhibitor of TRL4) mRNA, and it also inhibits tumor growth by targeting SPRED2 (an inhibitor of the ERK pathway). However, METTL3 enhances immunosuppression through the Jak1/STAT3 pathway. METTL14 (a writer) increases degradation of Ebi3 mRNA, promoting the antitumor function of CD8+ T cells. FTO (an eraser) reduces degradation of STAT1/PPAR-γ mRNA, promoting macrophage activation.