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The mechanisms by which m6A modification regulates NK cells
METTL3 enhances the antitumor function of NK cells by promoting SHP-2 (a critical mediator of IL-15-induced activation) translation. YTHDF2 (a writer) positively regulates NK cell division/proliferation by increasing Tardbp mRNA degradation. The STAT5–YTHDF2 positive feedback loop, which is downstream of IL-15, controls NK cell effector functions.
