Figure 5.
The mechanisms by which m6A modification regulates T cells
METTL3 promotes proliferation and differentiation of T cells via the JAK/STAT5 pathway by decreasing the expression of SOCS family proteins (SOCS1, SOCS3, and CISH). ALKBH5 (an eraser) enhances production of CXCL-2 and IFN-γ by targeting CXCL-2 and IFN-γ mRNA degradation. METTL3 also promotes T follicular helper (Tfh) development by stabilizing Tcf-7 mRNA to increase TCF-1 (a regulator of Tfh differentiation) expression. The VHL-HIF-1α axis regulates Tfh cell development in an m6A-dependent manner.