Table 2.
Mean age of HbSC vs HbSS patients with severe complications (standard deviation)
| Characteristics | HbSC | HbSS | P value∗ |
|---|---|---|---|
| Acute pain (≥ 3 episodes per y) only (n = 180) | 32.8 (8.2) | 30.5 (7.9) | .071 |
| ACS only (n = 34) | 32.7 (6.0) | 31.3 (9.1) | .667 |
| Severe symptomatic chronic anemia only (n = 4) | N/A | 39.8 (8.1) | N/A |
| Symptomatic AVN (n = 110) | 34.8 (6.8) | 32.8 (7.2) | .141 |
| Cerebrovascular accident/stroke (n = 10) | 36.0 (7.6) | 27.9 (10.0) | .247 |
| Priapism (n = 37) | 31.8 (5.8) | 28.5 (6.0) | .252 |
| Nephropathy (n = 61) | 26.9 (5.9) | 31.2 (7.6) | .154 |
| Proliferative SCD Retinopathy (n = 24) | 32.7 (7.3) | 22.3 (4.0) | .012 |
| Active chronic leg ulcer (n = 53) | N/A | 32.7 (7.2) | N/A |
| Systemic hypertension (n = 30) | 38.2 (6.0) | 40.3 (5.1) | .418 |
| Chronic pain (n = 266) | 35.2 (7.4) | 32.7 (7.2) | < .001 |
The causes of the chronic pain include AVN, osteoarthritis of the knee and elbow joints, spondylosis (both lumbar and cervical), and active chronic leg ulcers.
N/A, not available.
∗
t test.