Table 1.
Differences in baseline characteristics between responders and non-responders to vasopressin loading
| n | Responders | Non-responders | p value |
|---|---|---|---|
| MAP change > 22 mmHg | MAP change ≤ 22 mmHg | ||
| 62 | 30 | ||
| Age, years | 75.9 ± 11.6 | 77.7 ± 11.5 | 0.51 |
| Male, n (%) | 43 (69.4) | 20 (66.7) | 0.84 |
| Height, cm | 158.2 ± 8.4 | 159.9 ± 6.3 | 0.36 |
| Body weight, kg | 56.0 ± 13.8 | 52.0 ± 8.9 | 0.17 |
| SOFA | 8 (6, 10) | 8 (5, 11) | 0.93 |
| APACHEII | 19 (14, 23) | 20 (13.5, 25.5) | 0.99 |
| Mechanical ventilation, n (%) | 43 (69.4) | 20 (66.7) | 0.93 |
| Blood purification, n (%) | 22 (35.4) | 14 (46.7) | 0.22 |
| Extracorporeal membrane oxygenation, n (%) | 4 (6.5) | 2 (6.7) | 0.92 |
| Atrial fibrillation n (%) | 16 (25.8%) | 6 (21.4%) | 0.65 |
| Vasopressin administration from noradrenaline start, hours | 5 (1.4, 15.7) | 1.75 (0.5, 4.9) | 0.018 |
| Noradrenaline dose before loading, μg/kg/min | 0.3 (0.22, 0.48) | 0.4 (0.3, 0.68) | 0.14 |
| Catecholamine index before loading | 30 (22, 47.5) | 47 (30, 67.5) | 0.15 |
| Max lactate within 24 h of loading, mmol/L | 2.6 (1.6, 4.6) | 4.7 (2.9, 8.1) | 0.008 |
| Vasopressin concentration, pg/ml | 5.8 (3.5, 10.6) | 6.7 (2.4, 19.8) | 0.76 |
| ACTH, pg/ml | 22.8 (9.7, 45.4) | 36.4 (22.3, 92.5) | 0.018 |
| cOrtisol, μg/dL | 21.9 (14.6, 34.0) | 26.1 (20.0, 41.2) | 0.11 |
Data were expressed as a mean ± standard deviation for normally distributed continuous variables or median (interquartile range) for non-normally distributed continuous variables. Categorical variables were expressed as n (%)
MAP mean arterial pressure; SOFA sequential organ failure assessment; APACHE acute physiology and chronic health evaluation; ACTH adrenocorticotropic hormone