Table 2.

Differences in outcomes between responders and non-responders to vasopressin loading

n	Responder	Non-responder	p value
	MAP change > 22 mmHg	MAP change ≤ 22 mmHg
	62	30
Primary outcome
Catecholamine index change 6 h	− 10 (− 15, − 5)	0 (0, 28.8)	< 0.0001
Secondary outcomes
Catecholamine index change 2 h	− 2 (− 10, 0)	0 (− 3.75, 20)	0.0005
Catecholamine index change 4 h	− 10 (− 12, 0)	0 (0, 22.5)	< 0.0001
In-hospital death, n (%)	23 (37.7)	16 (57.1)	0.087
Length of ICU stay, days	7 (5, 9)	6.5 (4.3, 11)	0.78
Length of hospital stay, days	21 (12, 47.5)	18.5 (6.25, 42.3)	0.44
Duration of mechanical ventilation, days	5 (4, 9)	6 (4.3, 10.3)	0.39
Duration of blood purification, days	5 (2.8, 19.3)	6(4.5, 12)	0.86
Urine output 0–2 h, ml/h	60 (20, 102.5)	20 (0, 70)	0.025
Urine output 2–4 h, ml/h	70 (20, 130)	50 (6.3, 92.5)	0.089
Urine output 4–6 h, ml/h	82.5 (35, 195)	42.5 (6.3, 107.5)	0.067
Fluid volume IN 24 h, ml	2217 (1525, 3052)	2809 (2026, 3483)	0.040
Fluid volume OUT 24 h, ml	1015 (674, 2460)	964 (331, 1756)	0.073
Net IN–OUT balance, ml	1007 (159, 1625)	1668 (966, 2736)	0.0064
Pre lactate, mmol/L	1.7 (1.3, 3.1)	2.4 (1.4, 4.7)	0.061
Post lactate, mmol/L	1.6 (1.2, 2.4)	2.8 (1.65, 5.45)	0.0009
Lactate change 2 h, mmol/L	− 0.2 (− 0.8, 0.1)	0.1 (− 0.38, 0.6)	0.0058
Pre pH	7.40 (7.32, 7.48)	7.38 (7.30, 7.44)	0.32
Post pH	7.41 (7.33, 7.46)	7.40 (7.29, 7.44)	0.48
Vasopressin administration time, hours	40 (26.5, 61.3)	45 (14.3, 85.9)	0.82
Steroid use after vasopressin administration, n (%)	15 (24.6)	16 (57.1)	0.0031
Digital ischemia, n (%)	0 (0)	2 (7.1)	0.030
Mesenteric ischemia, n (%)	1 (1.6)	1 (3.6)	0.58
Cardiac ischemia, n (%)	1 (1.6)	0 (0)	0.38

Data were expressed as a mean ± standard deviation for normally distributed continuous variables or median (interquartile range) for non-normally distributed continuous variables. Categorical variables were expressed as n (%)

MAP mean arterial pressure; ICU intensive care unit