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. 2023 Jul 22;23:689. doi: 10.1186/s12885-023-11078-9

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© The Author(s) 2023, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — A, B Heterogeneous responses of organoids derived from breast cancer patients exposed to paclitaxel and doxorubicin. The fitted dose–response curves illustrate the responses of the organoids to paclitaxel and doxorubicin (n = 3 biologically independent data are presented as mean ± SD). C Organoids recapitulate the histological features of primary Breast Cancer Organoids. Immunohistochemical analyses show the examples of luminal A, luminal B, HER2-enriched and triple negative BCs, respectively. Scale bar = 100 µm. D The heat map of sensitivity and resistivity of organoids against paclitaxel and doxorubicin. Summary of the 2 FDA-approved compounds used in the drug sensitivity and resistance testing (DSRT) and the results. The corresponding colors for IC50 are depicted in the legend. Error bars represent the SEM of technical duplicates. ** < p = 0.01, N.S.: not significant (one-way ANOVA). Data analyses were performed using the GraphPad Prism software