Table 4.
Univariable and multivariable regression table for annualized rate of change RWT
| Annualized rate of change RWT | Univariable model (n = 59) | Multivariable model (n = 53) | ||
|---|---|---|---|---|
| β | p | β | p | |
| Demographics (baseline) | ||||
| Age, per year | 0.000072 | 0.74 | − 0.000161 | 0.53 |
| Male versus female | 0.0097 | 0.15 | 0.0043 | 0.57 |
| Race | ||||
| White | REF | REF | REF | REF |
| Black | 0.0012 | 0.86 | … | … |
| Hispanic | 0.0067 | 0.21 | ||
| Other | − 0.017 | 0.37 | ||
| BMI, per kg/m2 | 0.00014 | 0.75 | … | … |
| RA characteristics | ||||
| RA duration (square root), per year | 0.0021 | 0.19 | − 0.000041 | 0.98 |
| Joint deformities (square root) | 0.0023 | 0.20 | … | … |
| DAS28CRP (baseline) | − 0.00055 | 0.77 | … | … |
| DAS28CRP (follow-up) | − 0.0031 | 0.64 | … | … |
| Averaged DAS28CRP (baseline + fu) | − 0.0011 | 0.62 | … | … |
| CDAI (square root) (baseline) | − 0.000050 | 0.98 | … | … |
| CDAI (square root) (follow-up) | − 0.00012 | 0.63 | − 0.0027 | 0.12 |
| Averaged CDAI (baseline + fu) | − 0.0013 | 0.38 | … | … |
| RF (baseline) > 40, units | − 0.00499 | 0.32 | … | … |
| CCP (baseline) > 250, units | − 0.0033 | 0.52 | … | … |
| Square root CRP (baseline), per mg/liter | 0.00047 | 0.78 | … | … |
| Square root CRP (follow-up), per mg/liter | 0.0010 | 0.41 | … | … |
| Log IL-6, (baseline) per mg/liter | 0.0018 | 0.41 | … | … |
| Log IL-6, (follow-up) per mg/liter | 0.0029 | 0.19 | 0.0018 | 0.51 |
| Log BNP (baseline), per pg/mL | − 0.0044 | 0.33 | … | … |
| Log troponin-I (baseline), per pg/mL | − 0.00032 | 0.89 | … | … |
| Log galectin-3 (baseline), per ng/mL | 0.0084 | 0.13 | 0.0099 | 0.096 |
| RA medications (follow-up) | ||||
| NSAID use, yes versus no | 0.0013 | 0.81 | … | … |
| Prednisone use, yes versus no | − 0.0048 | 0.63 | … | … |
| Hydroxychloroquine use, yes versus no | 0.015 | 0.19 | 0.025 | 0.11 |
| TNF inhibitors use, yes versus no | − 0.0045 | 0.93 | … | … |
| Tocilizumab use, yes versus no | 0.0033 | 0.69 | … | … |
| CV risk factors | ||||
| Current smoker, yes versus no | − 0.0044 | 0.66 | … | … |
| SBP (baseline), per mm/Hg | 0.00023 | 0.11 | 0.00035 | 0.028 |
| SBP (follow-up), per mm/Hg | 0.00012 | 0.42 | … | … |
| Statin use (follow-up), yes versus no | 0.0048 | 0.42 | … | … |
| ASA use (follow-up), yes versus no | 0.011 | 0.053 | 0.012 | 0.099 |
| Total cholesterol, per mg/dl | − 0.000018 | 0.82 | … | … |
| LDL, per mg/dl | − 0.00011 | 0.23 | … | … |
| HDL, per mg/dl | 0.00014 | 0.32 | … | … |
| Prob > F | … | 0.071 | ||
| R2 | … | 0.29 | ||
| Adjusted R2 | … | 0.14 | ||