Table 5.
Univariable and multivariable regression table for baseline CRM
| Baseline concentric remodeling (CRM) | Univariable (n = 151) | Multivariable (n = 137) | ||||
|---|---|---|---|---|---|---|
| OR | 95% CI | p-value | OR | 95% CI | p-value | |
| Demographics | ||||||
| Age, per year | 1.05 | 1.00–4.10 | 0.029 | 1.04 | 0.98–1.099 | 0.21 |
| Male versus female | 1.48 | 0.44–4.92 | 0.52 | 1.15 | 0.28–4.68 | 0.85 |
| Race | ||||||
| White | REF | REF | 0.54 | REF | REF | 0.36 |
| Non-White | 0.74 | 0.28–1.97 | 0.56 | 0.16–1.92 | ||
| BMI, per kg/m2 | 1.07 | 0.98–1.14 | 0.12 | 1.03 | 0.95–1.12 | 0.41 |
| RA characteristics | ||||||
| RA duration (square root), per year | 0.87 | 0.64–1.18 | 0.37 | … | … | … |
| Joint deformities (square root) | 0.88 | 0.59–1.30 | 0.52 | … | … | … |
| CDAI (square root), per unit | 1.22 | 0.89–1.66 | 0.22 | 1.30 | 0.88–1.92 | 0.19 |
| DAS28CRP, per unit | 1.19 | 0.83–1.70 | 0.29 | … | … | … |
| RF > 40, units | 0.54 | 0.20–1.46 | 0.22 | … | … | … |
| CCP > 250, units | 0.61 | 0.23–1.61 | 0.32 | 0.84 | 0.27–2.65 | 0.77 |
| Square root CRP, per mg/L | 0.90 | 0.59–1.38 | 0.63 | … | … | … |
| Log IL-6, per pg/mL | 1.02 | 0.68–1.53 | 0.92 | 0.85 | 0.52–1.39 | 0.52 |
| RBM IL-6 (binary) | 0.69 | 0.18–2.56 | 0.58 | … | … | … |
| Log BNP, per pg/mL | 2.3 | 0.53–9.88 | 0.26 | … | … | … |
| Log troponin-I, per pg/mL | 1.34 | 0.87–2.08 | 0.18 | … | … | … |
| Log galectin-3, per ng/mL | 2.72 | 0.93 − 7.98 | 0.069 | 2.31 | 0.62–8.59 | 0.21 |
| RA medication | ||||||
| NSAID use, yes versus no | 0.91 | 0.34–2.48 | 0.86 | … | … | … |
| Prednisone use, yes versus no | 1.43 | 0.52–3.90 | 0.49 | … | … | … |
| Hydroxychloroquine use, yes versus no | 1.92 | 0.56–6.50 | 0.30 | … | … | … |
| Methotrexate use, yes versus no | 1.46 | 0.50–4.33 | 0.49 | … | … | … |
| TNF inhibitor use, yes versus no | 0.63 | 0.20–2.02 | 0.43 | … | … | … |
| Tocilizumab use, yes versus no | 15.3 | 1.31 − 177.78 | 0.029 | … | … | … |
| CV risk factors | ||||||
| Current smoker, yes versus no | 0.98 | 0.20–4.71 | 0.98 | … | … | … |
| Ever smoker, yes versus no | 2.46 | 0.92 − 6.53 | 0.072 | 1.91 | 0.65–5.60 | 0.24 |
| SBP (baseline), mm/Hg | 1.02 | 0.99–1.05 | 0.13 | 1.01 | 0.98–1.04 | 0.58 |
| Statin use, yes versus no | 0.65 | 0.14–3.05 | 0.59 | … | … | … |
| ASA use, yes versus no | 0.98 | 0.20–4.71 | 0.98 | … | … | … |
| Total cholesterol, per mg/dl | 0.99 | 0.98–1.01 | 0.46 | … | … | … |
| LDL, per mg/dl | 0.99 | 0.98–1.01 | 0.50 | … | … | … |
| Square root HDL, per mg/dl | 1.04 | 0.70–1.57 | 0.83 | … | … | … |
| Prob > χ2 | 0.21 | |||||
| Pseudo R2 | 0.12 | |||||