Fig. 3.

Overview of the time periods used by clinical team to either wean or escalate study drug. A 24-hour period for weaning or escalation, per hospital guidelines (light blue bar). Multiple vertical green lines represent dosing intervals; in this example the infant is receiving an opioid every 3 h. If the opioid dose does not change after 24 h of dosing, the infant enters a 12-h period of study protocol guideline (purple bar) to ensure that hospitals either wean or escalate and do not remain on the same dose. This approach will be applied to both weaning interventions