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. 2023 Jul 21;24:466. doi: 10.1186/s13063-023-07378-x

Table 3.

Sample size estimates

Power N per arm Total N Morphinea N Methadonea N LOT-difference SD Alpha
0.9 251 502 352 150 2 6.9 0.05
0.9 296 592 414 178 2 7.5 0.05
0.9 337 674 472 202 2 8.0 0.05
0.85 214 428 300 128 2 6.9 0.05
0.85 253 506 354 152 2 7.5 0.05
0.85 288 576 403 173 2 8.0 0.05
0.80 187 374 262 112 2 6.9 0.05
0.80 221 442 309 133 2 7.5 0.05
0.80 252 504 353 151 2 8.0 0.05

LOT Length of treatment days, SD Standard deviation

aIncludes infants randomized to either rapid-wean or slow-wean interventions