Table 3.
Sample size estimates
Power | N per arm | Total N | Morphinea N | Methadonea N | LOT-difference | SD | Alpha |
---|---|---|---|---|---|---|---|
0.9 | 251 | 502 | 352 | 150 | 2 | 6.9 | 0.05 |
0.9 | 296 | 592 | 414 | 178 | 2 | 7.5 | 0.05 |
0.9 | 337 | 674 | 472 | 202 | 2 | 8.0 | 0.05 |
0.85 | 214 | 428 | 300 | 128 | 2 | 6.9 | 0.05 |
0.85 | 253 | 506 | 354 | 152 | 2 | 7.5 | 0.05 |
0.85 | 288 | 576 | 403 | 173 | 2 | 8.0 | 0.05 |
0.80 | 187 | 374 | 262 | 112 | 2 | 6.9 | 0.05 |
0.80 | 221 | 442 | 309 | 133 | 2 | 7.5 | 0.05 |
0.80 | 252 | 504 | 353 | 151 | 2 | 8.0 | 0.05 |
LOT Length of treatment days, SD Standard deviation
aIncludes infants randomized to either rapid-wean or slow-wean interventions