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. 2023 Jul 21;27:72. doi: 10.1186/s40824-023-00385-8

Fig. 5.

Fig. 5

Drug delivery system to improve the delivery efficacy of bioTPD. (A) A polymeric nanoparticle-mediated delivery system was used for combination therapy of phototherapy, and PROTAC-engaged immunotherapy. (B) The antibody-tethered Nano-ERASER was transported into cells (1) and subsequently released antibodies upon a high level of glutathione (GSH) (2). The antibodies primed the corresponding POI (3) and drive them for degradation through Trim-Away pathway (4). The figure was created in BioRender.com