Table 2.

Selection of targeted drugs during pregnancy and lactation in patients with SpA

Drugs	Can be used peri-conception (Yes /No)	Can be used in the first trimester (Yes/No)	Can be used in the second/ third trimester (Yes/No)	Can be used in breastfeeding (Yes/No)
Infliximab	Yes	Yes	Stop at gestation week 20	Yes, but lack of evidence
Etanercept	Yes	Yes	can be used in first and second trimester, but should be discontinued in the third trimester	Yes, but lack of evidence
Adalimumab	Yes	Yes	Can be used in the first and second trimester, but should be discontinued in the third trimester	Yes, but lack of evidence
Certolizumab pegol	Yes	Yes	Yes, but lack of evidence	Yes, but lack of evidence
Golimumab	No data	No data	No data	No data
Ustekinumab	Yes, but lack of evidence	No data	No data	No data
Secukinumab	Yes, but lack of evidence	Yes, but lack of evidence	No data	No data