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. 2023 Jul 21;21:175. doi: 10.1186/s12964-023-01173-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Inhibited LAP after oxyHb exposure. Immunofluorescence analysis of pHrodo and LC3 (a) showing the number of particles (b) and LC3 + particles (c) after oxyHb exposure. The relative mRNA expression of Becn1 and Rubicon (d). The relative mRNA expression of Atg5 and Atg7 (e). The relative mRNA expression of Ctsb and Ctsl (f). Protein bands (g) and semi-quantitative analysis (h) showing the protein expression of BECN1, RUBICON, LC3 II, ATG5, ATG7, LAMP1 and P62. Data are presented as mean ± SEM. ****-P < 0.0001, ***-P < 0.001, **-P < 0.01, *-P < 0.05; ns, non-significant. Scale bar: 3 μm