Fig. 5.

MAL2 downregulation inhibits BC lung metastasis in vivo. A Schematic flowchart of the MDA-MB-231 cells in vivo metastasis model. B Representative photographs of lung metastatic nodules developed in mice 6 weeks after injection of MAL2-silencing or control MDA-MB-231 cells. Red arrowheads denote metastatic nodules established in lungs. C Representative HE images of nude mouse lung 6 weeks following injection of MDA-MB-231 sh-NC and sh-MAL2. Scale bar: 250 μm. All data are expressed as mean ± SD. ** P < 0.01