Table 2.
Genotype frequencies of single nucleotide polymorphisms in HTR2B according to status of gestational diabetes mellitus
| SNPs | Without GDM | With GDM | OR (CI 95%) | P value |
|---|---|---|---|---|
| HTR2B (N) | 443 | 453 | ||
| rs765458 | ||||
| AA | 0.248 | 0.239 | 0.90 (0.64–1.27) | 0.55 (RD) |
| AG | 0.542 | 0.518 | 1.02 (0.82–1.27) | 0.82 (CD) |
| GG | 0.210 | 0.243 | ||
| MAF | 0.481 | 0.502 | ||
| rs10187149 | ||||
| AA | 0.324 | 0.338 | ||
| AC | 0.509 | 0.498 | 0.94 (0.77–1.45) | 0.70 (RD) |
| CC | 0.167 | 0.164 | 0.92 (0.74–1.14) | 0.46 (CD) |
| MAF | 0.422 | 0.413 | ||
| rs10194776 | ||||
| TT | 0.277 | 0.279 | ||
| TC | 0.526 | 0.495 | 0.99 (0.79–1.52) | 0.57 (RD) |
| CC | 0.197 | 0.226 | 0.96 (0.78–1.19) | 0.74 (CD) |
| MAF | 0.479 | 0.473 | ||
| rs17619600 | ||||
| TT | 0.839 | 0.614 | 2.32 (1.61–3.37) | < 0.0001 (RD) |
| TC | 0.149 | 0.329 | 2.15 (1.53–3.09) | < 0.0001 (CD) |
| CC | 0.012 | 0.057 | ||
| MAF | 0.087 | 0.223 |
Analyses were performed in the rare dominant (RD) and in the co-dominant (CD) models after adjustment for age, pre-gestational body mass index and weight gain by binary logistic regression analysis
CI confidence interval; GDM gestational diabetes mellitus; MAF minor allele frequency; OR odds ratio; SNPs single nucleotide polymorphisms