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. 2023 Jul 21;21:176. doi: 10.1186/s12964-023-01196-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — DNase-1 inhibited tumor growth in relation to a decrease in microvessel density. a Subcutaneous tumor samples from nude mice treated with DNase-1 and the control group (n = 5). b Growth curve of subcutaneous tumor in nude mice; all values are presented as means ± SDs. ****p < 0.0001. c Subcutaneous tumor sample weights; all values are presented as means ± SDs. ***p < 0.001. d Microvessel densities in tumor tissues of the control and DNase-1 treatment groups as assessed by immunohistochemical staining. CD31 is a positive index; magnification × 20; scale bars: 50 μm. e The microvessel density was calculated using Image J software; all values are presented as means ± SDs, ****p < 0.0001. h, i The levels of NETs in tumor tissues of the control and DNase-1 treatment groups were measured via immunohistochemical staining. cit-H3 and MPO are positive markers; magnification × 20; scale bars: 50 μm. f, g Statistics of the NET coverage area were calculated using Image J software. NET, neutrophil extracellular trap; MPO, myeloperoxidase; cit-H3, citrullinated histone H3; SD, standard deviation