Table 3.

Subgroup analysis for the association between LAR and mortality

	Cardiovascular mortality				All-cause mortality
	N (%)	LAR HR (95% CI)	P value	p-int	N (%)		LAR HR (95% CI)	P value	p-int
Age				0.044					< 0.001
<65 years	33 (0.3%)	0.496 (0.173, 1.425)	0.193		255 (2.6%)	0.686 (0.436, 1.080)		0.103
≥ 65 years	117 (4.5%)	0.071 (0.013, 0.395)	0.003		617 (23.5%)	0.164 (0.083, 0.325)		< 0.001
Gender				0.487					0.066
Male	98 (1.6%)	0.209 (0.050, 0.877)	0.032		516 (8.6%)	0.282 (0.160, 0.498)		< 0.001
Female	52 (0.8%)	0.382 (0.118, 1.238)	0.109		356 (5.6%)	0.545 (0.325, 0.912)		0.021
CAD				0.978					0.636
Yes	35 (2.6%)	0.298 (0.055, 1.633)	0.163		190 (14.4%)	0.476 (0.223, 1.013)		0.054
No	115 (1.0%)	0.306 (0.102, 0.922)	0.035		682 (6.1%)	0.389 (0.246, 0.615)		< 0.001
Diabetes				0.124					0.258
Yes	48 (2.5%)	0.749 (0.165, 3.412)	0.709		312 (16.2%)	0.529 (0.287, 0.972)		0.040
No	102 (1.0%)	0.187 (0.059, 0.593)	0.004		560 (5.3%)	0.346 (0.209, 0.572)		< 0.001
Lipid-lowering medication				0.843					0.116
Yes	67 (2.5%)	0.275 (0.068, 1.117)	0.071		316 (11.9%)	0.602 (0.320, 1.133)		0.116
No	83 (0.8%)	0.327 (0.097, 1.095)	0.070		556 (5.7%)	0.331 (0.204, 0.538)		< 0.001
Hypertriglyceridemia				0.064					0.355
Yes	50 (1.6%)	0.814 (0.185, 3.586)	0.785		246 (8.0%)	0.545 (0.286, 1.039)		0.065
No	100 (1.1%)	0.143 (0.044, 0.467)	0.001		626 (6.7%)	0.376 (0.231, 0.611)		< 0.001

h Hazard ratio, CI Confidence interval, p-int p for interaction. Hypertriglyceridemia was defined as serum TG level > 1.7 mmol/L. Adjusted for age, sex, race, drinking, smoking, hypertension, diabetes, coronary artery disease, serum triglyceride level, and lipid-lowering drugs as required