Table 1.
Patient characteristics.
| Patient characteristics | All patients (N = 137) |
|---|---|
| Sex, male/female (% male) | 93/44 (67.9%) |
| Age, years (IQR) | 58.1 (50.0–65.6) |
| BMI, kg/m2 (IQR) | 26.0 (23.5–29.6) |
| Aetiology | |
| ALD, n (%) | 65 (47.4%) |
| Viral hepatitis, n (%) | 20 (14.6%) |
| ALD + viral hepatitis, n (%) | 12 (8.8%) |
| NASH, n (%) | 17 (12.4%) |
| Cholestatic, n (%) | 1 (0.7%) |
| Other, n (%) | 22 (16.1%) |
| Decompensated ACLD, n (%) | 86 (62.8%) |
| Ascites, n (%) | 77 (56.2%) |
| EASL stage | |
| 0, n (%) | 13 (9.5%) |
| 1, n (%) | 12 (8.8%) |
| 2, n (%) | 26 (19.0%) |
| 3, n (%) | 7 (5.1%) |
| 4, n (%) | 46 (33.6%) |
| 5, n (%) | 33 (24.1%) |
| MELD, points (IQR) | 12.0 (9.0-15.0) |
| CTP score, points (IQR) | 6.0 (5.0-8.0) |
| CTP stage | |
| A, n (%) | 71 (51.8%) |
| B, n (%) | 52 (38.0%) |
| C, n (%) | 14 (10.2%) |
| Bilirubin, mg/dl (IQR) | 1.1 (0.7–1.9) |
| Albumin, g/dl (IQR) | 37.0 (33.5–40.3) |
| INR, units (IQR) | 1.4 (1.2–1.5) |
| Sodium, mmol/L (IQR) | 139.0 (136.5–140.0) |
| HVPG, mmHg (IQR) | 16 (11–20) |
| MAP, mmHg (IQR) | 101 (91–110) |
| LSM, kPa (IQR) | 35.1 (20.2–57.1) |
| Serum total cortisol, μg/dl (IQR) | 10.0 (6.2–13.2) |
| Cortisol binding globulin, μg/ml (IQR)1 | 41.5 (34.4–47.5) |
| Serum free cortisol, ng/ml (IQR)1 | 5.0 (2.9–7.2) |
| Bile acids, μmol/L (IQR) | 14.2 (6.5–41.4) |
| Total cholesterol, mg/dl (IQR) | 139.0 (117.5–167.5) |
| HDL cholesterol, mg/dl (IQR) | 44.0 (35.5–55.0) |
| LDL cholesterol, mg/dl (IQR) | 77.2 (58.5–100.8) |
| Statin intake, n (%) | 21 (9.9%) |
| IL-6, ng/dl (IQR) | 8.0 (4.0–15.5) |
| WBC, G/L (IQR) | 4.9 (3.6–6.2) |
| CRP, mg/dl (IQR) | 0.3 (0.1–0.8) |
ACLD, advanced chronic liver disease; ALD, alcohol-related liver disease; CTP, Child-Turcotte-Pugh; CRP, C-reactive protein; HVPG, hepatic venous pressure gradient; IL-6, interleukin-6; INR, international normalized ratio; LSM, liver stiffness measurement; LT, liver transplantation; MAP, mean arterial pressure; MELD, model for end-stage liver disease; NASH, non-alcoholic liver disease; WBC, white blood count.
1
available in 133 patients.