Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jul 21;13:132. doi: 10.1186/s13578-023-01083-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Crown 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 3 — a Confocal images (inverted for signal visibility) showing epithelial and mesenchymal cell state markers in MDA-MB-231 TNBC cells across control or treated conditions (TGF- β, CuCl2, TEPA or CuCl2 + TEPA). Segmented cell nuclei and cytoplasm outlines shown (red). All scale bars 20 μm. b Violin plots showing quantification of single cell mean fluorescence intensities. c Violin plots showing quantification of single cell nuclear-to-cytoplasmic (N:C) mean intensity ratio. Total cells per treatment condition: control = 21848; TGF- β = 17743; CuCl2 = 19153; TEPA = 25200; and CuCl2 + TEPA = 18705. 14000–23000 cells per marker, 2000–6000 cells per marker per treatment group. Results of two-sided Mann–Whitney-Wilcoxon testing with Bonferroni correction: ns = (5.00e-02 < p < = 1.00e + 00), *: (1.00e-02 < p < = 5.00e-02), **: (1.00e-03 < p < = 1.00e-02), ***: (1.00e-04 < p < = 1.00e-03), ****: (p < = 1.00e-04)