Table 1.

List of genes and proteins’ phosphorylation affected by TEPA in RNA-Seq, Real-Time PCR, and western blot analysis of MDA-MB-231, SH-SY5Y, DIPG007, and DIPG010 cell lines. These genes and proteins are important in the migration, and invasion of cancer cells via dysregulation of TGF-β and EMT pathways

Cell lines	GenesIprotein symbol
	Downregulated	Upregulated
MDA-MB-231	TGF-β1, TGFBR2, SPARC, SNAI2, SMAD2, p-SMAD2, MMP-2, MMP-9, MMP-14, MMP- 11, MMP-15, Vimentin, RAC2, BCL2, PLOD2, PLAT, MARCKSLl, CCR7, PAK l, ZYX, LAMA4, p-AKT, p-ERK l/2	CDKN1A, TIMP3, TIMP4, E-cadherin, (CDH l)
SH-SY5Y	TGF-β1, p-SMAD2, SMAD2, MMP-9, MMP-14, Vimentin, ZEBl, ZYX, RACl, PLAT, p-AKT, p-ERK l/2	TGIFl, CDKN1A
DIPG007	SMAD2, p-SMAD2, MMP-2, MMP-9, MMP-14, Vimentin, ZYX, VCAN, PXN, AKT, p-AKT, ERK l/2, p-ERK l/2	CDKN1C
DIPG010	TGF-β1, SPARC, N-cadherin (CDH2), Vimentin, MMP-2, ZYX, LAMA4, PLAT, VCAN