Table 1.
Immunocompromised rodent models for filarial parasites
| Parasite | Host | Host Phenotype | References |
|---|---|---|---|
| Brugia malayi | SCID mouse | T cell and B cell deficient | [11] |
| Onchocerca volvulus | SCID mouse, athymic nude rats | As above; T cell deficient rats | [12] |
| Brugia malayi, Onchocerca ochengi | SCID mouse | As above | [13] |
| Onchocerca volvulus | NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ (NSG) mice; NOD-Rag1tm1Mom IL2rgtm1Wjl/SzJ (NRG) mice NSG-humanized mice | Defects in macrophages, dendritic cells, complement, T cells, B cells, NK cells, eosinophils, cytokine signalling | [14] |
| Loa loa | SCID mice, NSG mice, RAG −/− γc −/− mice | As above; T cell, B cell and NK cell deficient | [15] |
| Dirofilaria immitis | NSG mice, NRG mice | As above | [16, 18] |
| Dirofilaria immitis | Rat, steroid treated | Broad immunomodulatory effects, deficient in inflammatory responses | [17] |