Table 5.

Clinical trials targeting the immune landscape for the treatment of metastatic colorectal cancer

Type of cancer vaccine	Tumour-associated antigen	Trial ID	Phase	Subject
Cancer cell vaccine	Autologous cancer cells	NCT00016133	Phase I/II	Stage II or III colon cancer
Cancer cell vaccine	Autologous cancer cells	NCT02448173	Phase III	Stage II colon cancer
DC vaccine	Mutated peptides	NCT03730948	Phase I	Stage I and II hypermutated colorectal cancer
DC vaccine	Autologous tumour homogenate	NCT02919644	Phase II	Stage IV colorectal cancer
Peptide vaccine	GUCY2C–PADRE	NCT01972737	Phase I	Stage I or stage II colon cancer
Peptide vaccine	12 unique epitopes	NCT03391232	Phase I	mCRC

mCRC metastatic colorectal cancer