Fig. 3.

Effects of genetic variants in CLU on clusterin protein levels. A, B No significant effects of either rs11136000 (A: marking the LD block) or rs9331888 (B) in CLU were identified on plasma levels of clusterin). C Clusterin levels were not significantly different between APOE genotypes. Data are shown as mean ± SD and were analysed statistically using Kruskal–Wallis test with Dunn’s multiple comparisons post-hoc test. Numbers for homozygote and heterozygote carriers of each SNP are shown in Table 1. D Manhattan plot of GWAS results of the whole sample set using plasma clusterin levels as an intermediate phenotype found no significant variants