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. 2023 Jul 21;20:169. doi: 10.1186/s12974-023-02850-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Effects of genetic variants in CR1 on sCR1 protein levels. A, B The minor allele (G) at rs6691117 was significantly associated with a decrease in sCR1, while the minor (A) allele at rs6656401 was strongly associated with increased sCR1 levels in plasma. Data are shown as mean ± SD and were analysed using Kruskal–Wallis with Dunn’s multiple comparisons post-hoc tests. *p < 0.05; **p < 0.01; ***p < 0.001. Numbers for homozygote and heterozygote carriers of each SNP are shown in Table 1. C Manhattan plot of GWAS results on the whole sample set (n = 1667) with plasma sCR1 as endophenotype identifies multiple loci in the CR1 gene on chromosome 1 significantly associated with changes in plasma sCR1 levels. D, E LocusZoom plots in the region identify a cluster of significant SNPs in high LD with rs6656401 (D), while rs6691117 was below the significance threshold (E)