Fig. 6.

SNPs in CFH are significantly associated with changes in plasma FH levels. A Minor allele (T) carriers at rs6664877 had significantly higher plasma FH levels compared to major allele carriers in the combined cohort and in AD and controls analysed separately. Data are means ± SD and were analysed statistically using Mann–Whitney tests. **p < 0.01; ***p < 0.001. Numbers for homozygote and heterozygote carriers of the SNP are shown in Table 1. B Manhattan plot of GWAS results on the whole sample set (n = 1713) using plasma FH as endophenotype identifies loci in chromosome 1 significantly associated with changes in plasma FH levels. C LocusZoom analysis identifies a cluster of significant SNPs within CFH and a second cluster in the adjacent CFHR4 gene that influence plasma FH levels. Rs6664877 was the most significant hit