Table 2.

Factors associated with clinical relapse after nucleo(s)tide analogue withdrawal in multivariable Cox regression analysis.

Variable	HR (95% CI)	p value
Pretreatment HBV DNA <20,000 IU/ml	0.379 (0.262–0.550)	<0.001
EOT HBcrAg undetectable	0.635 (0.493–0.817)	<0.001
EOT HBsAg <100 IU/ml	0.569 (0.433–0.748)	<0.001
Age	1.023 (1.013–1.033)	<0.001
EOT ALT	1.004 (1.001–1.008)	0.023
TDF therapy	1.300 (1.032–1.637)	0.026
Sex	1.184 (0.921–1.521)	0.187
Asian ethnicity	1.947 (1.205–3.147)	0.006

ALT, alanine aminotransferase; EOT, end of treatment; HBcrAg, hepatitis B core-related antigen; HR, hazard ratio; TDF, tenofovir.