Table 3.

Factors associated with HBsAg loss after nucleo(s)tide analogue withdrawal in multivariable Cox regression analysis.

Variable	HR (95% CI)	p value
Pretreatment HBV DNA <20,000 IU/ml	2.872 (1.790–4.609)	<0.001
EOT HBcrAg undetectable	2.042 (1.262–3.304)	0.004
EOT HBsAg <100 IU/ml	7.551 (4.653–12.252)	<0.001
Age	0.985 (0.963–1.007)	0.184
EOT ALT	0.989 (0.975–1.002)	0.097
TDF therapy	0.996 (0.602–1.650)	0.989
Sex	1.196 (0.711–2.014)	0.500
Asian ethnicity	0.342 (0.176–0.665)	0.002

ALT, alanine aminotransferase; EOT, end of treatment; HBcrAg, hepatitis B core-related antigen; HR, hazard ratio; TDF, tenofovir.