Fig. 2.

Meal-response study to investigate metabolism in family members and matched controls.

(A) Study design. (B) ApoB levels. Participants are grouped according to age and sex matching to family members F, J, K, Q, and M (Table S1). MTP residue 564 is indicated (TT/TI/II). PNPLA3 or TM6SF2 in parentheses indicates individuals homozygous for variant rs738409 or rs58542926, respectively. (C) Serum ApoB-100 (mean levels ± standard deviation). ¹Milk and cornflakes. ²80–175 min between breakfast start and pre-lunch sample. ³From participants J and 1 used to derive cell lines. ApoB, apolipoprotein B; ApoB-100, apolipoprotein B-100; HV, healthy volunteers; MTP, microsomal triglyceride transfer protein; NAFLD, non-alcoholic fatty liver disease; SNP, single-nucleotide polymorphism.