Table 2:
Potential predictors of nonadherence in study population
| Variables | Cases (n=88) | Controls (n=250) | Test value | Significance of null hypothesis |
|---|---|---|---|---|
| Number of medications | χ2 = 17.194 | P=0.002 | ||
| 1 | 22 (25%) | 102 (40.8%) | ||
| 2 | 30 (34.3%) | 96 (38.4%) | ||
| 3 | 22 (25%) | 34 (13.6%) | ||
| 4 | 14 (15.9%) | 16 (6.4%) | ||
| 6 | 0 (0%) | 2 (0.8%) | ||
| Stopped using any medication in last 6 months Y/N | 12/76 (13.6%/86.4%) | 40/210 (16%/84%) | χ2 = 0.279 | P=0.597 |
| Dosing regimen | χ2 = 10.100 | P=0.005 | ||
| Every day | 82 (93.2%) | 246 (99.2%) | ||
| As needed | 6 (6.8%) | 2 (0.8%) | ||
| Using medication in the last 7 d | 86 (97.7%) | 250 (100%) | χ2 = 5.670 | P=0.017 |
| Y/N | 2 (2.3%) | |||
| Effect of medication | χ2 = 6.238 | P=0.044 | ||
| Moderate | 8 (9.1%) | 24 (9.7%) | ||
| Well | 70 (79.5%) | 214 (86.3%) | ||
| I don’t know | 10 (11.4%) | 10(4%) | ||
| Burden of taking the drug | χ2 = 20.650 | P<0.001 | ||
| No burden | 46 (53.5%) | 164 (75.2%) | ||
| Little | 34 (39.5%) | 52 (23.9%) | ||
| A lot | 4 (4.7%) | 0 (0%) | ||
| I don’t know | 2 (2.3%) | 2 (0.9%) | ||
| Issues with remembering the dosing regimen | χ2 = 18.685 | P<0.001 | ||
| No | 58 (65.9%) | 198 (86.8%) | ||
| A little | 24 (27.3%) | 26 (11.4%) | ||
| A lot | 6 (6.8%) | 4 (1.8%) | ||
| Issues with purchasing a medication | χ2 = 20.714 | P<0.001 | ||
| No | 66 (75%) | 184 (80.7%) | ||
| A little | 20 (22.7%) | 16 (7%) | ||
| A lot | 2 (2.3%) | 28 (12.3%) | ||
| Issues with monthly renewal of medication | χ2 = 9.256 | P=0.010 | ||
| No | 68 (77.3%) | 186 (80.9%) | ||
| A little | 20 (22.7%) | 30 (13%) | ||
| A lot | 0 (0%) | 14 (6.1%) | ||
| Time of diagnosis | 24/64 | 92/148 | χ2 = 3.446 | P=0.063 |
| <5 / >5 years | (27.3%/72.7%) | (38.3%/61.7%) | ||
| Current HTA control compared to last year | χ2 = 19.042 | P=0.001 | ||
| Better | 38 (43.2%) | 124 (51.2%) | ||
| The same | 32 (36.4%) | 98 (40.5%) | ||
| Worsen | 8 (9.1%) | 2 (0.8%) | ||
| I don’t know | 6 (6.8%) | 6 (2.5%) | ||
| I don’t control regularly | 4 (4.5%) | 12 (5%) | ||
| Family history of HTA Y/N | 74/14 (84.1%/15.9%) | 168/74 (69.4%/30.6%) | χ2 = 7.101 | P=0.008 |
| Regular self-control of TA Y/N | 72/16 (81.8%/18.2%) | 218/26 (89.3%/10.7%) | χ2 = 3.315 | P=0.069 |
| Information from healthcare practitioner Y/N | 70/18 (79.5%/20.5%) | 200/44 (82%/18%) | χ2 = 0.250 | P=0.617 |
Results are presented as frequency in percent or mean plus standard deviation. Statistical significance was confirmed by Mann-Whitney or Chi square test, depending the type of variables, with the statistical threshold of 0.05.