Table 2.

Summary of Early-Terminated Publications

First Author, Year (Reference No.)	CSP Study No.	Publication Title	Clinicaltrials.Gov National Clinical Trial No.	Condition or Disease	Intervention	Primary Outcome	Actual No.	Expected No.	Primary Reason for Early Termination	Secondary Reason For Early Termination	Sponsor
Lin, 2020 (6)	553	Chemotherapy after prostatectomy for high-risk prostate carcinoma: a phase III randomized study	NCT00132301	Prostate cancer	Docetaxel plus prednisone vs. standard of care	Progression-free survival	298	636	Enrollment		CSP; Sanofi
Kamalesh, 2013 (7)	557	Percutaneous coronary intervention versus coronary bypass surgery in United States veterans with diabetes	NCT00326196	Coronary artery disease	PCI vs. CABG	Death or nonfatal MI	198	790	Enrollment		CSP
Brilakis, 2018 (8)	571	Drug-eluting stents versus bare-metal stents in saphenous vein grafts: a double-blind, randomized trial	NCT01121224	Saphenous vein graft atherosclerosis	BMS vs. DES	Death, MI, or revascularization	597	762	Enrollment	Funding	CSP
Rosenheck, 2011 (9)	555	Long-acting risperidone and oral antipsychotics in unstable schizophrenia	NCT00132314	Schizophrenia/schizoaffective disorder	IM risperidone vs. oral antipsychotic	Time to hospitalization	369	450	Enrollment	Clinical practice	CSP
Lo, 2010 (10)	558	Robot-assisted therapy for long-term upper-limb impairment after stroke	NCT00372411	Stroke	Robot-assisted therapy vs. intensive therapy vs. standard of care	Fugl-Meyer Assessment for Motor Recovery scale	127	158	Enrollment	Futility	CSP; Burke Medical Research Institute
Bauman, 2013 (11)	535	The effect of oxandrolone on the healing of chronic pressure ulcers in persons with spinal cord injury a randomized trial	NCT00101361	Pressure ulcer	Oxandrolone vs. placebo	Time to full healing	212	400	Futility		CSP
McFall, 2010 (12)	519	Integrating tobacco cessation into mental health care for posttraumatic stress disorder: a randomized controlled trial	NCT00118534	Mental health, PTSD, tobacco use disorder	Integrated care for smoking cessation vs. standard of care	Prolonged abstinence	943	1,400	Benefit		CSP
O’Dell, 2013 (13)	551	Therapies for active rheumatoid arthritis after methotrexate failure	NCT00405275	Rheumatoid arthritis	Etanercept vs. placebo	Change in disease activity score for 28 joints	353	450	Funding		CSP
Fried, 2013 (14)	565	Combined angiotensin inhibition for the treatment of diabetic nephropathy	NCT00555217	Kidney disease, type 2 diabetes	Losartan monotherapy vs. losartan plus lisinopril	Rate of glomerular filtration rate decline, development of end-stage renal disease, and death	1,448	1,850	Safety		CSP
Fan, 2012 (15)	560	A comprehensive care management program to prevent chronic obstructive pulmonary disease hospitalizations: a randomized, controlled trial	NCT02036294	COPD	COPD self-management education vs. standard of care	Time to first hospitalization for COPD	426	960	Safety		CSP
Holodniy, 2011 (16)	512	Results of antiretroviral treatment interruption and intensification in advanced multi-drug resistant HIV infection from the OPTIMA Trial	NCT00050089	HIV infection	No ARDFP vs. ARDFP; standard ART vs. mega-ART (5 or more anti-HIV drugs)	New or recurrent AIDS or death	368	390	Clinical practice		CSP; MRC; CIHR

Abbreviations: AIDS, acquired immunodeficiency syndrome; ARDFP, antiretroviral drug–free period; ART, antiretroviral therapy; BMS, bare-metal stent; CABG, coronary artery bypass grafting; CIHR, Canadian Institutes of Health Research; COPD, chronic obstructive pulmonary disease; CSP, Cooperative Studies Program Study; DES, drug-eluting stent; HIV, human immunodeficiency virus; IM, intramuscular; MI, myocardial infarction; MRC, Medical Research Council; PCI, percutaneous coronary infusion; PTSD, post-traumatic stress disorder; VA, Veterans Affairs.