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McCulloch and Neuhaus (36) test for association between the estimated random effect and assessment time process for (A) the bupropion group, (B) the sertraline group, and (C) the venlafaxine group. Solid lines represent the locally estimated scatterplot smoothing fit, and shaded areas represent the 95% CI for the fit. The Spearman correlations are 0.08 (P = 0.3), 0.07 (P = 0.3), and 0.20 (P = 0.006) for the bupropion, sertraline, and venlafaxine arms, respectively.
