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. Author manuscript; available in PMC: 2024 Jan 1.
Published in final edited form as: Diabetes Obes Metab. 2022 Sep 12;25(1):56–67. doi: 10.1111/dom.14843

Figure 5. GLP-1 Receptor Knockout Eliminates Dual GIP/GLP-1 Receptor Agonism-Induced Preference Shift between 5-Day Choice Chow and 60% High-Fat Diet (HFD) in Mice.

Figure 5.

Effect of once daily injections [vehicle or tirzepatide (TZP)] in wildtype (WT) and GLP-1 receptor knockout (KO) mice on daily intake of chow (A) and 60% HFD (B). Five-day cumulative intake of chow (C), intake of 60% HFD (D), and body weight change (E). Daily average intake of chow and 60% HFD as Kcals (F) and as a percentage of total Kcal intake (G). Direct comparisons are indicated with letter sets (a,b or x,z). N=4–6 per treatment group.