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Pharmacokinetic Parameters of Tirzepatide in Male and Female CD-1 mice Following a Single Subcutaneous Administration.
| Dose | Tmax | Cmax | AUC0-inf | T1/2 | CL/F |
|---|---|---|---|---|---|
| nmol/kg | (hr) | (nmol/L) | (hr*nmol/L) | (hr) | (mL/hr/kg) |
| 625 | 12 | 2538 | 71698 | 11.9 | 8.72 |
Abbreviations: AUC0–inf = area under the plasma concentration versus time curve from 0 to infinity, Cmax = maximum plasma concentration, Tmax = time of Cmax, T1/2 = half-life, CL/F = clearance.
