Skip to main content
. Author manuscript; available in PMC: 2024 Jan 1.
Published in final edited form as: Diabetes Obes Metab. 2022 Sep 12;25(1):56–67. doi: 10.1111/dom.14843

Table 2.

Mean Pharmacokinetic Parameters of Tirzepatide in Female Sprague Dawley Rats Following a Single Subcutaneous Administration.

Dose Tmax Cmax AUC0–96 T1/2 CL/F
nmol/kg (hr) (nmol/L) (hr*nmol/L) (hr) (mL/hr/kg)
31 12 127 3742 9.3 8.31
104 12 310 10040 10.3 10.3

Abbreviations: AUC0–96hr = area under the plasma concentration versus time curve from 0 to 96 hours, Cmax = maximum plasma concentration, Tmax = time of Cmax, T1/2 = half-life, CL/F = clearance.