Table 3.
Ongoing clinical trials involving EVs for the prediction of metastatic progression in cancer patients (data collected from http://clinicaltrials.gov, accessed in Dec 2022).
| Clinical Trial | Cancer Type | Identifier |
|---|---|---|
| Contents of circulating extracellular vesicles: biomarkers in colorectal cancer patients | CRC | NCT04523389 |
| Development of novel imaging and laboratory biomarkers to monitor the liver pre-metastatic niche and guide treatment of colon cancer: a pilot study | NCT03432806 | |
| Diagnostic and prognostic values of EUS-FNA specimens and circulating exosomal small RNA in patients with pancreatic cancer | PDAC | NCT04636788 |
| Circulating exosomes as potential prognostic and predictive biomarkers in advanced gastric cancer patients: a prospective observational study (“EXO-PPP Study”) | Gastric cancer | NCT01779583 |
| Exosomes-derived ncRNAs as biomarkers in cholangiocarcinoma patients | Cholangiocarcinoma | NCT03102268 |
| Non-coding RNA in the exosome of the epithelia ovarian cancer | Epithelia ovarian cancer | NCT03738319 |
| A prospective study of predicting prognosis and recurrence of thyroid cancer via new biomarkers, urinary exosomal thyroglobulin and galectin-3 | Thyroid cancer | NCT03488134 |
| Study of exosomes in monitoring patients with sarcoma (EXOSARC) | Sarcoma | NCT03800121 |
| A pilot study of circulating exosome RNA as diagnostic and prognostic markers in lung metastases of primary high-grade osteosarcoma | Osteosarcoma | NCT03108677 |
| Feasibility of exosome analysis in cerebrospinal fluid during the diagnostic workup of metastatic meningitis from breast cancer | Breast cancer | NCT05286684 |
| Interest of circulating tumor DNA in digestive and gynecologic/breast Cancer | Breast cancer/ Digestive cancer/ Gynecologic cancer | NCT04530890 |
| Validating the miR Scientific Sentinel™ platform (Sentinel PCC4 assay) in men undergoing core needle biopsy due to suspicion of prostate cancer for distinguishing between no cancer, low-, intermediate- and high-risk prostate cancer | Prostate cancer | NCT04100811 |
| Quantification and purification of circulating prostasomes as diagnostic tool for prostate cancer detection | NCT03694483 | |
| A prospective, randomized blinded, shared decision impact trial of the ExoDx Prostate (IntelliScore), EPI test, in men presenting for initial biopsy. | NCT03235687 | |
| To investigate the diagnostic accuracy of exosomal microRNA in predicting the aggressiveness of prostate cancer in Chinese patients | NCT03911999 | |
| Identification and characterization of predictive factors of onset of bone metastases in cancer patients | Not specified | NCT03895216 |