Table 2.
Summary of results of the secondary outcomes: Acetaminophen vs. Indomethacin
| Outcome | Studies | Participants | Statistical method | Effect estimate | P-value |
|---|---|---|---|---|---|
| RR [95% CIs] | |||||
| GI Bleed | 3 | 347 | Risk Ratio (M-H, Random, 95% CI) | 0.43 [0.06, 3.40] | 0.43 |
| Pulmonary hemorrhage | 3 | 347 | Risk Ratio (M-H, Random, 95% CI) | 0.92 [0.14, 6.00] | 0.93 |
| NEC | 3 | 347 | Risk Ratio (M-H, Random, 95% CI) | 0.37 [0.14, 0.95] | 0.04 |
| ROP | 2 | 259 | Risk Ratio (M-H, Random, 95% CI) | 0.71 [0.27, 1.86] | 0.49 |
| ROP needing treatment | 2 | 91 | Risk Ratio (M-H, Random, 95% CI) | 1.35 [0.60, 3.06] | 0.47 |
| Sepsis | 3 | 314 | Risk Ratio (M-H, Random, 95% CI) | 1.02 [0.58, 1.79] | 0.95 |
| IVH | 2 | 275 | Risk Ratio (M-H, Random, 95% CI) | 0.80 [0.34, 1.84] | 0.59 |
| BPD | 2 | 94 | Risk Ratio (M-H, Random, 95% CI) | 1.22 [0.85, 1.76] | 0.28 |
| Death | 2 | 114 | Risk Ratio (M-H, Random, 95% CI) | 0.90 [0.40, 2.02] | 0.79 |
BPD, bronchopulmonary dysplasia; GI, gastrointestinal; IVH, intraventricular hemorrhage; NEC, necrotizing enterocolitis; ROP, retinopathy of prematurity.