Table 3.
Chlorpromazine (CPZ) Equivalents and Clinical Symptom Severity Associations with Structural Brain Morphometry in Clinical High-Risk
| SOPS | ||||
|---|---|---|---|---|
| Components | Positive | Negative | Disorganized | General |
|
|
|
|||
| Cortical Thickness | ||||
| Frontal-Parietal | .06 | −.11 | −.01 | −.06 |
| Frontal | .13 | .02 | .03 | .06 |
| Temporal | .03 | −.01 | −.05 | .00 |
| Occipital | −.01 | −.10 | .12 | −.07 |
| Cingulate | .17 | .05 | .08 | −.04 |
| Cortical Surface Area | ||||
| Frontal-Parietal | −.11 | .02 | −.12 | .05 |
| Temporal | −.11 | −.09 | −.12 | .02 |
| Frontal | −.10 | .10 | .07 | .10 |
| Occipital | .01 | .08 | −.03 | .08 |
| Subcortical Volume | ||||
| Hippocampus/Amygdala/Accumbens | −.10 | −.32† | −.20 | −.12 |
| Thalamus/Pallidum | .08 | −.04 | .16 | .07 |
| Caudate/Putamen | −.05 | .02 | .12 | .17 |
| Ventricular Volume | ||||
| All Ventricles | −.07 | .08 | −.09 | .00 |
| Cerebellar Volume | ||||
| Whole Cerebellum | .02 | .09 | .03 | .12 |
Note. SOPS=Scale of Psychosis-Risk Symptoms. Correlations for cortical thickness adjusted for age, scanning site, and sex. Correlations for cortical surface area and subcortical/ventricular/cerebellar volume adjusted for age, scanning site, sex, and intracranial volume.
†
p<.05 but did not survive FDR correction.