Fig. 1.

a Study design and b patient disposition flow chart. This manuscript focuses on pharmacokinetic data from part A of NCT03333824; part B of NCT03333824 is an investigation of the effect of adavosertib on the QT interval, results of which are reported separately. *Informed consent received; ^†A number of patients enrolled more than once; there were 49 unique enrollments; ^‡Study treatment refers to treatment with either cocktail or adavosertib; ^§One each as a result of death (pancreatic cancer), study termination by the sponsor, and withdrawal by the patient. bid twice daily