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. 2023 Jul 8;14(9):1537–1548. doi: 10.1007/s13300-023-01440-2
Individuals initially diagnosed with type 2 diabetes (T2D) might exhibit positivity for diabetes-associated autoantibodies (DAA +).
We investigated the prevalence of DAA positivity in a group of individuals with T2D referred to a tertiary diabetes centre in Slovakia within a pre-specified period of time.
Approximately 1 in 5 individuals with a formal diagnosis of T2D were found to be positive for at least one of the tested DAA (anti-GAD65, IA-2A or IAA).
Only approximately 85% of the DAA + individuals aged > 30 years at the time of diabetes diagnosis met the current diagnostic criteria for latent autoimmune diabetes of adults (LADA).
Several pathological processes linked with distinct types of diabetes can develop in parallel in a single person, including insulin resistance and autoimmune insulitis.