Table 3.

Area Under the ROC Curve for GFAP in distinguishing between trauma patients with and without MTBI (ability to detect MTBI among a cohort of trauma patients).

Time post-injury N =  + MTBI/ − MTBI	GFAP (Male) N = 362	GFAP (Female) N = 222	GFAP (All) N = 584	P-Value
Enrollment	0.73 (0.68–0.78)	0.75 (0.69–0.82)	0.73 (0.69–0.77)	0.631
Male n = 213/149
Female n = 112/110
4 h	0.71 (0.65–0.77)	0.75 (0.67–0.82)	0.73 (0.68–0.77)	0.415
Male n = 162/106
Female n = 88/73
8 h	0.73 (0.63–0.83)	0.90 (0.81–1.00)	0.78 (0.70–0.86)	0.027
Male n = 71/21
Female n = 38/6
12 h	0.73 (0.61–0.85)	0.87 (0.75–0.99)	0.77 (0.68–0.87)	0.158
Male n = 57/14
Female n = 32/4
16 h	0.81 (0.70–0.91)	0.89 (0.76–1.00)	0.83 (0.74–0.91)	0.425
Male n = 55/9
Female n = 30/2
20 h	0.78 (0.66–0.91)	0.82 (0.64–0.99)	0.79 (0.69–0.90)	0.750
Male n = 52/11
Female n = 22/3
24 h	0.79 (0.68–0.91)	0.81 (0.63–0.99)	0.80 (0.70–0.90)	0.891
Male n = 46/12
Female n = 21/2
36 h	0.80 (0.66–0.94)	0.91 (0.75–1.00)	0.81 (0.70–0.93)	0.388
Male n = 27/12
Female n = 17/1
48 h	0.90 (0.80–1.00)	0.77 (0.49–1.00)	0.86 (0.76–0.96)	0.452
Male n = 27/10
Female n = 11/2
60 h	0.94 (0.85–1.00)	0.60 (0.28–0.92)	0.88 (0.78–0.99)	0.250
Male n = 23/7
Female n = 10/1
72 h	0.84 (0.69–0.99)	0.88 (0.61–1.00)	0.84 (0.71–0.97)	0.813
Male n = 21/8
Female n = 8/1
84 h	0.94 (0.83–1.00)	0.83 (0.54–1.00)	0.90 (0.79–1.00)	0.597
Male n = 16/5
Female n = 6/1
96 h	0.84 (0.68–1.00)	n/a	0.85 (0.70–1.00)	–
Male n = 16/5
Female n = 4/0
108 h	0.86 (0.60–1.00	n/a	0.82 (0.57–1.00)	–
Male n = 7/2
Female n = 4/0
120 h	0.88 (0.66–1.00)	n/a	0.90 (0.73–1.00)	–
Male n = 8/3
Female n = 2/0
132 h	0.92 (0.71–1.00)	n/a	0.94 (0.78–1.00)	–
Male n = 6/2
Female n = 2/0
144 h	0.88 (0.65–1.00)	n/a	0.90 (0.72–1.00)	–
Male n = 8/2
Female n = 2/0
156 h	0.83 (0.54–1.00)	n/a	0.83 (0.58–1.00)	–
Male n = 6/2
Female n = 3/0
168 h*	0.81 (0.53–1.00)		0.85 (0.62–1.00)	–
Male n = 8/2
Female n = 2/0

Shown is the performance of GFAP in males versus females.

*Includes results from 180 h.