Table 4.

Area under the ROC Curve for UCH-L1 in distinguishing between trauma patients with and without TBI ((ability to detect MTBI among a cohort of trauma patients).

Time post-Injury N =  + MTBI/ − MTBI	UCH-L1 (Male) N = 362	UCH-L1 (Female) N = 222	UCH-L1 (All) N = 584	P-Value
Enrollment	0.62 (0.56–0.67)	0.70 (0.64–0.77)	0.66 (0.62–0.70)	0.079
Male n = 213/149
Female n = 112/110
4 h	0.59 (0.52–0.66)	0.69 (0.61–0.77)	0.63 (0.58–0.69)	0.064
Male n = 162/106
Female n = 88/73
8 h	0.66 (0.55–0.78)	0.74 (0.57–0.91)	0.65 (0.55–0.75)	0.485
Male n = 71/21
Female n = 38/6
12 h	0.62 (0.48–0.76)	0.78 (0.62–0.95)	0.63 (0.51–0.75)	0.217
Male n = 57/14
Female n = 32/4
16 h	0.72 (0.57–0.87)	0.66 (0.45–0.87)	0.67 (0.53–0.81)	0.762
Male n = 55/9
Female n = 30/2
20 h	0.59 (0.42–0.76)	0.41 (0.13–0.68)	0.53 (0.38–0.68)	0.382
Male n = 52/11
Female n = 22/3
24 h	0.56 (0.39–0.73)	0.48 (0.20–0.76)	0.52 (0.37–0.67)	0.737
Male n = 46/12
Female n = 21/2
36 h	0.66 (0.47–0.85)	0.91 (0.75–1.00)	0.61 (0.44–0.78)	0.073
Male n = 27/12
Female n = 17/1
48 h	0.65 (0.46–0.85)	0.32 (0–0.66)	0.58 (0.40–0.75)	0.184
Male n = 27/10
Female n = 11/2
60 h	0.67 (0.48–0.85)	0.65 (0.25–1.00)	0.60 (0.43–0.77)	0.946
Male n = 23/7
Female n = 10/1
72 h	0.52 (0.30–0.74)	0.81 (0.48–1.00)	0.52 (0.31–0.72)	0.218
Male n = 21/8
Female n = 8/1
84 h	0.51 (0.25–0.77)	0.42 (0.01–0.82)	0.50 (0.28–0.72)	0.808
Male n = 16/5
Female n = 6/1
96 h	0.49 (0.23–0.75)	n/a	0.40 (0.17–0.63)	–
Male n = 16/5
Female n = 4/0
108 h	0.63 (0.29–0.96)	n/a	0.42 (0.14–0.70)	–
Male n = 7/2
Female n = 4/0
120 h	0.52 (0.16–0.88)	n/a	0.42 (0.10–0.73)	–
Male n = 8/3
Female n = 2/0
132 h	0.42 (0.03–0.81)	n/a	0.31 (0–0.63)	–
Male n = 6/2
Female n = 2/0
144 h	0.38 (0.04–0.71)	n/a	0.30 (0.02–0.58)	–
Male n = 8/2
Female n = 2/0
156 h	0.71 (0.35–1.00)	n/a	0.50 (0.17–0.83	–
Male n = 6/2
Female n = 3/0
168 h*	0.72 (0.40–1.00)	n/a	0.63 (0.30–0.96)	–
Male n = 8/2
Female n = 2/0

Shown is the performance of UCH-L1 in males versus females.

*Includes results from 180 h.