Table 5.

Area Under the ROC Curve for GFAP in distinguishing between trauma patients with and without Intracranial Lesions on CT Scan of the head (ability to detect CT lesions).

Time post-injury N = CT + /CT-	GFAP (Male) N = 270	GFAP (Female) N = 144	GFAP (All) N = 414	P-Value
Enrollment	0.86 (0.77–0.94)	0.88 (0.77–1.00)	0.86 (0.79–0.93)	0.810
Male n = 26/244
Female n = 10/134
4 h	0.82 (0.72–0.92)	0.89 (0.73–1.00)	0.84 (0.75–0.92)	0.476
Male n = 24/187
Female n = 7/107
8 h	0.79 (0.66–0.92)	0.88 (0.73–1.00)	0.81 (0.70–0.91)	0.376
Male n = 19/69
Female n = 9/31
12 h	0.80 (0.66–0.94)	0.89 (0.73–1.00)	0.82 (0.71–0.93)	0.369
Male n = 19/50
Female n = 9/25
16 h	0.77 (0.63–0.92)	0.86 (0.61–1.00)	0.81 (0.68–9.31)	0.447
Male n = 18/44
Female n = 7/23
20 h	0.77 (0.61–0.92)	0.88 (0.67–1.00)	0.80 (0.67–0.92)	0.324
Male n = 18/42
Female n = 8/15
24 h	0.76 (0.59–0.92)	0.99 (0.99–1.00)	0.82 (0.70–0.95)	0.005
Male n = 16/40
Female n = 6/16
36 h	0.95 (0.89–1.00)	0.99 (0.99–1.00)	0.97 (0.92–1.00)	0.483
Male n = 10/27
Female n = 7/11
48 h	0.94 (0.87–1.00)	0.99 (0.99–1.00)	0.96 (0.90–1.00)	0.419
Male n = 11/25
Female n = 5/8
60 h	0.96 (0.89–1.00)	0.99 (0.99–1.00)	0.97 (0.93–1.00)	0.621
Male n = 9/19
Female n = 4/7
72 h	0.93 (0.82–1.00)	0.99 (0.99–1.00)	0.95 (0.88–1.00)	0.451
Male n = 8/19
Female n = 3/5
84 h	0.91 (0.78–1.00)	0.99 (0.99–1.00)	0.94 (0.86–1.00)	0.367
Male n = 8/12
Female n = 5/1
96 h	0.88 (0.71–1.00)	n/a	0.91 (0.78–1.00)	–
Male n = 8/13
Female n = 3/0
108 h	0.85 (0.58–1.00)	0.99 (0.99–1.00)	0.90 (0.71–1.00)	0.361
Male n = 5/4
Female n = 2/1
120 h	0.88 (0.67–1.00)	n/a	0.91 (0.75–1.00)	–
Male n = 6/5
Female n = 2/0
132 h	0.92 (0.71–1.00)	n/a	0.94 (0.78–1.00)	–
Male n = 6/2
Female n = 2/0
144 h	0.93 (0.76–1.00)	n/a	0.94 (0.81–1.00)	–
Male n = 7/3
Female n = 2/0
156 h	0.90 (0.66–1.00)	0.99 (0.99–1.00)	0.93 (0.76–1.00)	0.512
Male n = 5/3
Female n = 2/1
168 h*	0.79 (0.50–1.00)	n/a	0.84 (0.53–1.00)	–
Male n = 6/4
Female n = 2/0

Shown is the performance of GFAP in males versus females.

*Includes results from 180 h.