Table 6.

Area Under the ROC Curve for UCH-L1 in distinguishing between trauma patients with and without Intracranial Lesions on CT Scan of the head (ability to detect CT lesions).

Time post-injury N = CT + /CT−	UCH-L1 (Male) N = 270	UCH-L1 (Female) N = 144	UCH-L1 (All) N = 414	P-Value
Enrollment	0.73 (0.62–0.84)	0.84 (0.72–0.96)	0.77 (0.68–0.85)	0.264
Male n = 26/244
Female n = 10/134
4 h	0.71 (0.59–0.82)	0.75 (0.56–0.94)	0.73 (0.63–0.83)	0.750
Male n = 24/187
Female n = 7/107
8 h	0.64 (0.49–0.79)	0.74 (0.51–0.97)	0.67 (0.55–0.79)	0.434
Male n = 19/69
Female n = 9/31
12 h	0.69 (0.54–0.83)	0.79 (0.58–0.99)	0.71 (0.59–0.83)	0.405
Male n = 19/50
Female n = 9/25
16 h	0.67 (0.52–0.81)	0.74 (0.51–0.97)	0.70 (0.58–0.82)	0.622
Male n = 18/44
Female n = 7/23
20 h	0.61 (0.46–0.76)	0.63 (0.35–0.91)	0.61 (0.47–0.74)	0.893
Male n = 18/42
Female n = 8/15
24 h	0.56 (0.41–0.72)	0.90 (0.77–1.00)	0.64 (0.52–0.77)	0.006
Male n = 16/40
Female n = 6/16
36 h	0.57 (0.37–0.77)	0.75 (0.53–0.98)	0.61 (0.46–0.76)	0.280
Male n = 10/27
Female n = 7/11
48 h	0.70 (0.50–0.91)	0.65 (0.31–0.99)	0.67 (0.49–0.85)	0.796
Male n = 11/25
Female n = 5/8
60 h	0.70 (0.46–0.93)	0.43 (0.9–0.77)	0.60 (0.39–0.80)	0.211
Male n = 9/19
Female n = 4/7
72 h	0.71 (0.52–0.91)	0.33 (0–0.78)	0.63 (0.43–0.84)	0.105
Male n = 8/19
Female n = 3/5
84 h	0.72 (0.49–0.95)	0.50 (0.05–0.95)	0.65 (0.43–0.87)	0.544
Male n = 8/12
Female n = 5/1
96 h	0.80 (0.60–0.99)	n/a	0.63 (0.39–0.87)	–
Male n = 8/13
Female n = 3/0
108 h	0.88 (0.63–1.00)	0	0.61 (0.27–0.96)	< 0.001
Male n = 5/4
Female n = 2/1
120 h	0.75 (0.43–1.00)	n/a	0.59 (0.26–0.91)	–
Male n = 6/5
Female n = 2/0
132 h	0.42 (0.03–0.81)	n/a	0.31 (0–0.63)	–
Male n = 6/2
Female n = 2/0
144 h	0.55 (0.18–0.92)	n/a	0.44 (0.11–0.78)	–
Male n = 7/3
Female n = 2/0
156 h	0.80 (0.45–1.00)	0	0.57 (0.21–0.94)	< 0.001
Male n = 5/3
Female n = 2/1
168 h*	0.96 (0.84–1.00)	n/a	0.75 (0.39–1.00)	–
Male n = 6/4
Female n = 2/0

Shown is the performance of UCH-L1 in males versus females.

*Includes results from 180 h.