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. Author manuscript; available in PMC: 2023 Jul 23.
Published in final edited form as: Pharmacotherapy. 2023 Feb 14;43(7):609–621. doi: 10.1002/phar.2774

Table 3: Comparison of frequency of target attainment in early and late sepsis.

Two targets were assessed: concentrations above 1x Clinical Laboratory Standards Institute (CLSI) breakpoint or minimum inhibitory concentration (MIC) for 100% of dosing intervals and concentrations above 4x CLSI breakpoint/MIC for 100% of dosing intervals. Of those who did not attain targets in a specific phase, dosing interval in that phase of sepsis also provided. Q24h: every 24 hours; q12h: every 12 hours.

Early
(first 48 hours of
treatment)
(n=55)		 Late
(after 48 hours of
treatment)
(n=55)		 p-value
Number of patients who attained free ceftriaxone concentrations above CLSI breakpoint/MIC for 100% of dosing interval (%) 53 (96%) 45 (82%) 0.013
Number of patients who did NOT attain 1x MIC target 2 10
   q24h dosing 2 (100%) 10 (100%)
   q12h dosing 0 (0%) 0 (0%)
Number of patients who attained free ceftriaxone concentrations above 4 times CLSI breakpoint/MIC for 100% of dosing interval (%) 44 (80%) 41 (75%) 0.55
Number of patients who did NOT attain 4x MIC target 11 14
   q24h dosing 5 (45.4%) 12 (85.7%)
   q12h dosing 6 (54.6%) 2 (14.3%)