Table 2:
Effects of sleeve gastrectomy on body composition, calciotropic hormones, and biomechanical CT parameters 12 months after surgery vs. nonsurgical care
| Baseline measure | 12-month measure | 12-month change | p-value 12-months within groups | p-value 12-month change between groups | |||||
|---|---|---|---|---|---|---|---|---|---|
| Group | SG | NS | SG | NS | SG | NS | SG | NS | |
| Weight (kg) | 133.4 ± 25.2 | 120.6 ± 21.7 | 99.1 ± 26.9 | 121.9 ± 21.4 | −34.3 ± 13.6 (−39.5, −29.1) | 1.3 ± 7.1 (−1.4, 4.0) | <0.001 | 0.32 | <0.001* |
| BMI (kg/m2) | 47.4 ± 6.7 | 43.1 ± 5.5 | 35.1 ± 8.5 | 43 ± 5.5 | −12.3 ± 4.5 (−14, −10.6) | −0.05 ± 2.6 (−1, 0.9) | <0.001 | 0.92 | <0.001* |
| Visceral adipose tissue (VAT) (cm2) | 118.0 ± 50.6 | 111.9 ± 75.6 | 58.2 ± 36.6 | 123.5 ± 67.9 | −58.3 ± 36.4 (−73.3, −43.3) | 10.5 ± 33.4 (−2.4, 23.5) | <0.001 | 0.11 | <0.001* |
| Subcutaneous adipose tissue (SAT) (cm2) | 734.8 ± 162.5 | 698.7 ± 141.3 | 455.2 ± 172.1 | 724.0 ± 154.9 | −277.1 ± 156.1 (−341.6, −212.7) | 18.2 ± 81.6 (−13.4, 49.8) | <0.001 | 0.25 | <0.001* |
| Thigh Muscle (cm2) | 180.4 ± 32.7 | 173.7 ± 25.6 | 150.5 ± 26.6 | 176.1 ± 27.0 | −29.9 ± 23 (−39.4, −20.33) | 2.5 ± 11.4 (−1.9, 6.9) | <0.001 | 0.26 | <0.001* |
| Calcium (mg/dL) | 9.33 ± 0.29 | 9.28 ± 0.39 | 9.21 ± 0.29 | 9.19 ± 0.41 | −0.11 ± 0.32 (−0.24, 0.01) | −0.10 ± 0.35 (−0.23, 0.04) | 0.07 | 0.15 | 0.84 |
| 25-hydroxy vitamin D (ng/dL) | 26.24 ± 10.13 | 22.34 ± 7.55 | 30.24 ± 11.66 | 21.44 ± 5.6 | 3.75 ± 11.80 (−0.82, 8.32) | −1.22 ± 6.39 (−3.70, 1.26) | 0.05 | 0.32 | 0.06 |
| Phosphorus (mg/dL) | 3.62 ± 0.51 | 3.61 ± 0.66 | 3.86 ± 0.61 | 3.71 ± 0.48 | 0.25 ± 0.7 (−0.03, 0.53) | 0.1 ± 0.70 (−0.17, 0.37) | 0.07 | 0.45 | 0.42 |
| Parathyroid Hormone (pg/mL) | 39.74 ± 13.17 | 40.75 ± 16.35 | 35.62 ± 11.63 | 41.80 ± 21.91 | −3.45 ± 12.94 (−8.57, 1.67) | 2.04 ± 15.63 (−4.02, 8.11) | 0.18 | 0.50 | 0.16 |
| Vertebral body strength (N) | 10962 ± 1811 | 10233 ± 1935 | 10353 ± 1697 | 10337 ± 1852 | −609 ± 838 (−928, −291) | 103 ± 741 (−173, 380) | <0.001 | 0.45 | 0.001* |
| Vertebral bending stiffness (kNm/rad) | 2.87 ± 0.71 | 2.68 ± 0.66 | 2.79 ± 0.74 | 2.75 ± 0.71 | −0.08 ± 0.16 (−0.14, −0.02) | 0.07 ± 0.15 (0.01, 0.12) | 0.013 | 0.02 | <0.001* |
| Average vertebral BMD (mg/cm³) | 261 ± 30 | 252 ± 36 | 249 ± 29 | 252 ± 35 | −12 ± 12 (−16, −7) | 0 ± 13 (−5, 5) | <0.001 | 0.97 | <0.001* |
| Trabecular vertebral BMD (mg/cm³) | 250 ± 33 | 238 ± 35 | 235 ± 32 | 239 ± 34 | −15 ± 13 (−19, −10) | 2 ± 13 (−3, 7) | <0.001 | 0.49 | <0.001* |
| Cortical vertebral BMD (mg/cm³) | 285 ± 27 | 283 ± 40 | 279 ± 25 | 279 ± 38 | −6 ± 16 (−12, 0) | −4 ± 14 (−9, 2) | 0.05 | 0.19 | 0.52 |
Note. Data are reported as mean ± SD, data in parentheses indicate 95 % CI.
SG = Sleeve Gastrectomy; NS = Non-Surgical Control Group; rad=radian.
*
p<0.01 after controlling for baseline BMI